Publications

• Journal Articles
• Books
• Press Releases/Media

Journal Articles

The following articles have been published as part of the PI2 project from 2006 onward:

• Lynn DJ, Higgs R, Lloyd AT, O'farrelly C, Herve-Grepinet V, Nys Y, Brinkman FS, Yu PL, Soulier A, Kaiser P, Zhang G, Lehrer RI. Avian beta-defensin nomenclature: A community proposed update. Immunol Lett. 2007 May 15;110(1):86-9. PMID: 17467809
• Bylund J, Macdonald KL, Brown KL, Mydel P, Collins LV, Hancock RE, Speert DP. Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B. Eur J Immunol. 2007 Apr;37(4):1087-96. PMID: 17330823
• Hancock RE. The End of an Era. Nature Reviews Drug Discovery 2007 Jan;6(28):28.
• Atkinson-Grosjean J. Big science, boundary organizations and the academy. Academic Matters: The Journal of Higher Education. Spring. Also published in Restructuring the Academy: Current Realities and Future Directions. Proceedings of OCUFA conference, January 2007.
• Dusyk N. The Political and Moral Economies of Science: A Case Study of Genomics in Canada and the United Kingdom. Health Law Review 2007. 15(3).
• Brown KL, Cosseau C, Gardy JL, Hancock RE. Complexities of targeting innate immunity to treat infection. Trends Immunol. 2007 Apr 27; PMID: 17468048
• Scott MG, Dullaghan E, Mookherjee N, Glavas N, Waldbrook M, Thompson A, Wang A, Lee K, Doria S, Hamill P, Yu JJ, Li Y, Donini O, Guarna MM, Finlay BB, North JR, Hancock RE. An anti-infective peptide that selectively modulates the innate immune response. Nat Biotechnol. 2007 Apr;25(4):465-72. PMID: 17384586
• Mookherjee N, Hancock RE. Cationic host defence peptides: innate immune regulatory peptides as a novel approach for treating infections. Cell Mol Life Sci. 2007 Apr;64(7-8):922-33. PMID: 17310278
• Barsky A, Gardy JL, Hancock RE, Munzner T. Cerebral: a Cytoscape plugin for layout of and interaction with biological networks using subcellular localization annotation. Bioinformatics. 2007 Apr 15;23(8):1040-2. PMID: 17309895
• Hancock RE, Sahl HG. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat Biotechnol. 2006 Dec;24(12):1551-7. PMID: 17160061
• Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE. Sequence requirements and an optimization strategy for short antimicrobial peptides. Chem Biol. 2006 Oct;13(10):1101-7. PMID: 17052614
• Mookherjee N, Wilson HL, Doria S, Popowych Y, Falsafi R, Yu JJ, Li Y, Veatch S, Roche FM, Brown KL, Brinkman FS, Hokamp K, Potter A, Babiuk LA, Griebel PJ, Hancock RE. Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide. J Leukoc Biol. 2006 Dec;80(6):1563-74. PMID: 16943385
• Bowdish DM, Davidson DJ, Hancock RE. Immunomodulatory properties of defensins and cathelicidins. Curr Top Microbiol Immunol. 2006;306:27-66. PMID: 16909917
• Marr AK, Gooderham WJ, Hancock RE. Antibacterial peptides for therapeutic use: obstacles and realistic outlook. Curr Opin Pharmacol. 2006 Oct;6(5):468-72. PMID: 16890021
• Jenssen H, Hamill P, Hancock RE. Peptide antimicrobial agents. Clin Microbiol Rev. 2006 Jul;19(3):491-511. PMID: 16847082
• Barlow PG, Li Y, Wilkinson TS, Bowdish DM, Lau YE, Cosseau C, Haslett C, Simpson AJ, Hancock RE, Davidson DJ. The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol. 2006 Sep;80(3):509-20. PMID: 16793910
• Fulton DL, Li YY, Laird M, Horsman BGS, Roche FM, Brinkman FSL. Improving the specificity of high-throughput ortholog prediction. BMC Bioinformatics. 2006 May 28;7:270. PMID: 16729895
• Hancock REW, Brown KL, Mookerjee N. Host defence peptides from invertebrates – emerging antimicrobial strategies. Immunobiol. 2006. 211(4):315-22. PMID: 16697922
• Li P, Sun M, Ho B, Ding JL. The specificity of Sushi peptides for endotoxin and anionic phospholipids: potential application of POPG as an adjuvant for anti-LPS strategies. Biochem Soc Trans. 2006 Apr;34(2):270-2. PMID: 16545091
• Wang XW, Tan NS, Ho B, Ding JL. Evidence for the ancient origin of the NF-kappaB/IkappaB cascade: its archaic role in pathogen infection and immunity. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4204-9. PMID: 16537509
• Mookherjee N, Brown KL, Bowdish DM, Doria S, Falsafi R, Hokamp K, Roche FM, Mu R, Doho GH, Pistolic J, Powers JP, Bryan J, Brinkman FS, Hancock RE. Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol. 2006 Feb 15;176(4):2455-64. PMID: 16456005
• Lau YE, Bowdish DM, Cosseau C, Hancock RE, Davidson DJ. Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37. Am J Respir Cell Mol Biol. 2006 Apr;34(4):399-409. PMID: 16340000
• Brown KL, Hancock REW. Cationic host defense (antimicrobial) peptides. Curr Opin Immunol. 2006 Feb;18(1):24-30. PMID: 16337365

Book chapters

The following book chapters have been published as part of the PI2 project from 2006 onward:

• Mookerhjee N, Brown KL, Hancock REW. 2006. Cathelicidins: Cationic Host Defense and Antimicrobial Peptides. In Handbook of Biologically Active Peptides, Kastan A, ed.; Hancock REW, section ed. Academic Press Inc., London.
  
• Bowdish DME, Davidson DJ, Hancock REW. 2006. Immunomodulatory properties of defensins and cathelicidins. In Antimicrobial peptides and human disease, Shafer WM, ed. Springer Verlag, Berlin.

Press Releases/Media

PI2 in the news:

• Canada Research Chair Robert Hancock Finds New Ways to Battle Deadly Superbugs Canada Research Chairs Press Release, Dec. 8, 2006.
• Bob Hancock Awarded CIHR Michael Smith Prize in Health Research as Canada's Health Researcher of the Year CIHR Press Release, Nov. 22, 2006.
• Canadian Labs Debut Bioinformatics Tools For Ortholog Prediction, SNP Data Clustering. BioArray News, Apr 11, 2006
• Infectious Microbes May Adapt Faster Than Believed. Simon Fraser University Press Release, Dec 2, 2005.
• $17 Million Grant Helps Fight Disease. SFU News, Vol. 24, No. 6. Nov 17, 2005.
• New Genome Canada Funding for Natural Immunity Studies. The VIDO Report, Vol. 5, Iss. 4. Fall 2005.
• Immunity Project Receives $17M in Funding. Bioscienceworld.ca.
• Federal Funding Boosts SFU's Participation in Genomic Research. Simon Fraser University Press Release, Aug 25, 2005.